Table 3.
Patterns of mRNA expression of immune-related genes according to CD8 R/I ratio measured by immunohistochemical staining.
| CD8 R/I ratio < 1 | CD8 R/I ratio > 1 | p-value* | |||
|---|---|---|---|---|---|
| n | Median (1st -3rd quartile) | n | Median (1st–3rd quartile) | ||
| TCR related genes | |||||
| CD2 R/I ratio | 21 | 0.55 (0.38–0.98) | 12 | 1.10 (0.73–2.60) | 0.030 |
| CD27 R/I ratio | 21 | 0.41 (0.18–0.83) | 12 | 1.46 (0.81–2.51) | 0.007 |
| CD3D R/I ratio | 21 | 0.50 (0.27–0.74) | 12 | 1.25 (0.76–2.50) | 0.004 |
| CD7 R/I ratio | 21 | 0.58 (0.33–0.95) | 12 | 1.21 (0.57–2.96) | 0.018 |
| CD8A R/I ratio | 21 | 0.34 (0.26–0.75) | 12 | 1.41 (0.62–1.99) | 0.008 |
| CD96 R/I ratio | 21 | 0.60 (0.39–0.93) | 12 | 1.26 (0.70–2.79) | 0.011 |
| T cell inhibitory genes | |||||
| CTLA4 R/I ratio | 21 | 0.56 (0.31–0.81) | 12 | 1.23 (0.55–2.70) | 0.010 |
| PDCD1 R/I ratio | 21 | 0.53 (0.29–0.84) | 12 | 1.34 (0.46–2.18) | 0.030 |
TCR T-cell receptor, R/I ratio recurrent-to-initial ratio, SD standard deviation.
*Mann–Whitney’s U test.