Table 2.

Fixed-effect estimates in both primary and secondary outcomes.

Parameters	Changes in hand withdrawal latency					Feeling “high”
	B	SE	t	p	95% CI	B	SE	t	p	95% CI
Intercept	0.39	0.51	0.76	0.451	[− 0.63, 1.41]	3.02	1.55	1.95	0.054	[− 0.05, 6.09]
Sleep condition × drug condition	− 0.29	0.15	− 1.98	0.049	[− 0.57, − 0.001]	0.38	0.33	1.16	0.250	[− 0.27, 1.02]
Sleep condition	0.13	0.11	1.25	0.214	[− 0.08, 0.34]	− 0.38	0.24	− 1.57	0.121	[− 0.85, 0.10]
Drug condition	0.46	0.10	4.57	< 0.001	[0.26, 0.66]	1.67	0.30	5.62	< 0.0001	[1.08, 2.26]
Race (white vs. black)	− 0.16	0.09	− 1.75	0.081	[− 0.34, 0.02]	0.23	0.30	0.76	0.450	[− 0.37, 0.82]
Race (white vs. others)	− 0.004	0.10	− 0.04	0.967	[− 0.20, 0.19]	0.11	0.34	0.31	0.757	[− 0.58, 0.79]
Sex	0.09	0.09	0.97	0.331	[− 0.09, 0.28]	0.29	0.30	0.97	0.333	[− 0.30, 0.89]
Menstrual cycle	− 0.02	0.10	− 0.17	0.869	[− 0.21, 0.18]	0.08	0.25	0.31	0.760	[− 0.41, 0.56]
Age	0.01	0.01	2.29	0.023	[0.002, 0.02]	0.00	0.02	− 0.14	0.890	[− 0.04, 0.04]
BMI	0.02	0.01	1.85	0.065	[− 0.001, 0.04]	− 0.05	0.03	− 1.61	0.110	[− 0.12, 0.01]
Baseline systolic blood pressure	0.01	0.005	1.06	0.292	[− 0.004, 0.02]	− 0.03	0.01	− 2.29	0.023	[− 0.06, − 0.004]
Baseline diastolic blood pressure	− 0.02	0.01	− 2.73	0.007	[− 0.04, − 0.01]	0.04	0.02	1.58	0.116	[− 0.01, 0.08]
Baseline hand withdrawal latency	− 0.12	0.03	− 3.89	< 0.001	[− 0.19, − 0.06]	N/A

	Drug “liking”					Negative opioid effects
Intercept	0.85	1.45	0.58	0.559	[− 2.02, 3.71]	2.00	0.25	8.05	< 0.001	[1.51, 2.49]
Sleep condition × drug condition	0.23	0.31	0.74	0.463	[− 0.39, 0.85]	0.07	0.06	1.21	0.231	[− 0.05, 0.19]
Sleep condition	− 0.12	0.23	− 0.51	0.611	[− 0.57, 0.34]	0.001	00.04	0.03	0.979	[− 0.09, 0.09]
Drug condition	1.26	0.28	4.52	< 0.001	[0.71, 1.81]	0.15	0.05	3.21	0.002	[0.06, 0.25]
Race (white vs. black)	− 0.37	0.28	− 1.35	0.179	[− 0.92, 0.17]	0.03	0.05	0.65	0.515	[− 0.06, 0.12]
Race (white vs. others)	0.02	0.32	0.07	0.947	[− 0.61, 0.65]	0.02	0.05	0.46	0.644	[− 0.08, 0.13]
Sex	0.08	0.28	0.29	0.769	[− 0.47, 0.63]	0.08	0.05	1.69	0.093	[− 0.01, 0.17]
Menstrual cycle	− 0.01	0.24	− 0.06	0.952	[− 0.48, 0.45]	0.01	0.04	0.26	0.796	[− 0.07, 0.10]
Age	0.01	0.02	0.38	0.702	[− 0.03, 0.04]	− 0.001	0.003	− 0.47	0.636	[− 0.01, 0.01]
BMI	− 0.06	0.03	− 1.95	0.054	[− 0.12, 0.001]	− 0.02	0.00	− 3.31	0.001	[− 0.03, − 0.01]
Baseline systolic blood pressure	− 0.01	0.01	− .67	0.502	[− 0.03, 0.02]	0.000	0.002	0.09	0.926	[− 0.004, 0.005]
Baseline diastolic blood pressure	0.03	0.02	1.45	0.150	[− 0.01, 0.07]	0.002	0.004	0.52	0.605	[− 0.006, 0.009]