Table 1.

Expression of P2X4 in the CNS.

CNS regions	P2X4 mRNAa	P2X4 protein	P2rx4 reporter mice [82, 83]	P2X4 mCherryIN mice [84]	Cell type specificity	References
Amygdala	++	NA	NA	NA	NA
Basal ganglia	++	+	NA	NA	Neurons, Astrocytes	[48, 49, 71]
Cerebellum	++	++	++	+	Neurons	[48, 49, 57–59]
Cerebral cortex	+++	+	++	++	Neurons Astrocytesb	[52, 58, 59]
Hindbrain	+	++	++	NA	Neurons	[58]
Hippocampus	++	++	++	++	Neurons, Microglia, Astrocytesb	[13, 14, 57–59]
Hypothalamus	+	+	++	NA	Neurons	[51, 58]
Midbrain	+	+	++	NA	Neurons	[58]
Olfactory region	++	+++	+++	++	Neurons, Epithelial cells	[49, 57–59]
Spinal Cord	++	++	++	NA	Motoneurons, Microglia	[58, 89, 109]
Thalamus	+	+	+	NA	Neurons	[58]

Expression levels are indicated on a semi-quantitative scale where (+) indicates the presence and relative abundance of P2X4 expression. NA, no specific data set.

^aData from the Allen Brain Atlas obtained by in situ hybridization and available at http://mouse.brain-map.org/experiment/show/75551474.

^bP2X4 expression detected by electronic microscopy in astrocytes of P2X4mCherryIN mice using anti-RFP antibodies.