Table 2.

Mean (± SEM) effect of TNFsr averaged over the three doses tested compared to controls on alanine and aspartate amino transferases, creatine phosphokinase, glucose, leukocytes, platelets, creatinine, blood urea nitrogen, electrolytes, and arterial blood gas parameters at 4, 24 and 48 h after the start of peptidoglycan infusion

Time (h)	ALT [log10(U/l)]	AST [log10(U/l)]	CK [log10(U/l)]	Glucose [log10(mg/dl)]	White blood cells [log10(×103/µl)]	Neutrophils [log10(×103/µl)]
4	− 0.11 ± 0.12	− 0.10 ± 0.11	− 0.05 ± 0.07	− 0.001 ± 0.04	0.03 ± 0.04	0.15 ± 0.08
24	− 0.05 ± 0.22	0.01 ± 0.21	0.03 ± 0.13	0.06 ± 0.05	0.12 ± 0.08	0.15 ± 0.14
48	0.03 ± 0.23	− 0.10 ± 0.22	− 0.08 ± 0.13	0.05 ± 0.09	− 0.02 ± 0.09	− 0.01 ± 0.16

	Lymphocytes [log10 (×103/µl)]	Platelets [log10(×103/µl)]	Creatinine (µg/dl)	BUN [log10(mg/dl)]	Na (mmol/l)	K (mmol/l)
4	0.02 ± 0.04	0.04 ± 0.07	− 20.4 ± 40.7	− 0.03 ± 0.04	0.5 ± 0.03	− 0.4 ± 0.3
24	0.12 ± 0.07	0.23 ± 0.12	3.8 ± 80.3	0.08 ± 0.07	1.6 ± 0.6*	− 0.3 ± 0.3
48	0.004 ± 0.09	0.20 ± 0.14	35.7 ± 83.1	− 0.04 ± 0.07	0.7 ± 0.6	− 0.4 ± 0.3

	Cl (mmol/l)	pH	PaCO2 (mmHg)	HCO3 (mmol/L)	Lactate [log(mmol/L)]	PaO2 (mmHg)
4	0.2 ± 0.5	0.01 ± 0.02	2.1 ± 1.3	1.7 ± 1.0	− 0.18 ± 0.06*	− 5.6 ± 3.4
24	− 0.1 ± 1.0	0.03 ± 0.04	− 0.4 ± 2.5	1.9 ± 1.7	− 0.03 ± 0.09	− 1.3 ± 6.4
48	1.0 ± 1.0	− 0.02 ± 0.04	1.7 ± 2.6	1.7 ± 1.7	− 0.21 ± 0.09*	2.5 ± 6.6

ALT and AST, alanine and aspartate aminotransferases; CK, creatine phosphokinase; BUN, blood urea nitrogen; Na, sodium; K, potassium; Cl, chloride; PaCO₂, arterial carbon dioxide; HCO₃, bicarbonate; PaO₂, arterial oxygen

* p ≤ 0.05