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. 2020 Aug 18;36(11):1344–1354. doi: 10.1007/s12264-020-00557-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Inhibition of CCL2- and CFA-induced mechanical hyperalgesia by intrathecal injection of RS504393 or PD98059. A Prevention of CCL2 (100 ng, i.t.)-induced mechanical hyperalgesia by PD98059 (1 g, i.t.). B Reversal of CFA-induced mechanical hyperalgesia by PD98059 (1 μg, i.t.) given 1 day after CFA injection. C Reversal of CFA-induced thermal hyperalgesia by PD98059 (1 μg, i.t.) given 1 day after CFA injection. D Reversal of CFA-induced mechanical hyperalgesia by RS504393 (20 μg, i.t.) given 1 day after CFA injection. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n = 5–6.