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. 2020 Aug 18;36(11):1344–1354. doi: 10.1007/s12264-020-00557-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Diagram of the model. Following peripheral inflammation, directly released CCL2 acts on CCR2 on superficial dorsal horn neurons; this activates the ERK signaling cascade, leading to up-regulation of GluN2B on the cell membrane, and inducing chronic pain.