Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 5;14:590500. doi: 10.3389/fncel.2020.590500

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Blaschke, Demir, König, Abraham, Vay, Rabenstein, Olschewski, Hoffmann, Hoffmann, Hersch, Merkel, Hoffmann, Schroeter, Fink and Rueger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Increased microglia proliferation on soft substrates under resting conditions. (A) Representative images show Iba-1 positive microglia (red) double-stained for BrdU (green) to detect proliferating cells on substrates of 1.2 MPa, and (B) soft substrates of 0.6 kPa (scale bars = 100 μm). (C) Microglia proliferation measured by bromodeoxyuridine- (BrdU-) incorporation over 6 h increased with substrate elasticity (*p < 0.05 as compared to 1.2 MPa; n = 7). (D) In parallel, changes in microglia mRNA expression of Ki67 yielded an increasing yet statistically not significant trend on softer substrates (values displayed as fold change normalized to RPL13a and glass control; n = 5).