Table 5.

For all structures and hemispheres the spatial overlap between the “Gold standard” and the automated segmentation methods for both control and patients group

Method	Caudate nucleus
	Controls (N = 11)		Patients (N = 21)
	Left	Right	Left	Right
FSL-FIRST	0.84 ± 0.44	0.87 ± 0.03	0.86 ± 0.24	0.86 ± 0.04
FreeSurfer	0.85 ± 0.02	0.85 ± 0.02	0.82 ± 0.06	0.83 ± 0.05
GIF	0.85 ± 0.02	0.86 ± 0.01	0.83 ± 0.05	0.83 ± 0.06
volBrain	0.88 ± 0.02	0.88 ± 0.02	0.87 ± 0.03	0.87 ± 0.02

	Putamen
	Controls (N = 11)		Patients (N = 21)
	Left	Right	Left	Right
FSL-FIRST	0.89 ± 0.03	0.88 ± 0.04	0.88 ± 0.03	0.87 ± 0.04
FreeSurfer	0.89 ± 0.01	0.88 ± 0.01	0.85 ± 0.05	0.86 ± 0.03
GIF	0.82 ± 0.02	0.83 ± 0.01	0.80 ± 0.03	0.81 ± 0.02
volBrain	0.89 ± 0.01	0.89 ± 0.01	0.88 ± 0.02	0.89 ± 0.02

	Thalamus
	Controls (N = 11)		Patients (N = 21)
	Left	Right	Left	Right
FSL-FIRST	0.86 ± 0.02	0.86 ± 0.03	0.81 ± 0.05	0.81 ± 0.06
FreeSurfer	0.85 ± 0.02	0.86 ± 0.02	0.83 ± 0.05	0.83 ± 0.05
GIF	0.80 ± 0.01	0.77 ± 0.02	0.77 ± 0.03	0.75 ± 0.04
volBrain	0.87 ± 0.01	0.87 ± 0.01	0.84 ± 0.05	0.84 ± 0.04

The spatial overlap is given as the mean ± standard deviation of the Dice Similarity Coefficient. Values of patients are bold if they are significantly diferent from those of controls (p-value < 0.05). N = amount of subjects