Table I.

Coronary Vasomotion Disorders International Study (COVADIS) clinical criteria for the diagnosis of microvascular angina

COVADIS criteria for microvascular angina
1. Symptoms of myocardial ischemia	• Effort and/or rest angina  • Angina equivalents (i.e. shortness of breath)
2. Absence of obstructive CAD (>50% diameter reduction and/or FFR <0.80) by either:	• CT coronary angiography (CTCA)  • Invasive coronary angiography
3. Objective evidence of myocardial ischemia	• Ischemic ECG changes during an episode of chest pain  • Stress-induced chest pain and/or ischemic ECG changes in the presence of transient/reversible abnormal myocardial perfusion and/or wall motion abnormality
4. Evidence of impaired coronary microvascular function	• Impaired coronary flow reserve (cut-off values depending on methodology use between ≤2.0 and ≤ 2.5)  • Coronary microvascular spasm, defined as reproduction of symptoms, ischemic ECG shifts but no epicardial spasm during acetylcholine testing.  • Abnormal coronary microvascular resistance indices (e.g. IMR >25, HMR ≥2.5 mm Hg·cm-1·s)69  • Coronary slow flow phenomenon