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. 2020 Nov 5;11:575258. doi: 10.3389/fimmu.2020.575258

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Copyright © 2020 Kacew and Sweis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) FGFR3 gene alterations by cancer type based on available data from The Cancer Genome Atlas (TCGA) (only recurrent mutations and fusions—those comprising in >1% of mutations/fusions—were included). Potential mechanisms of improved response rate to FGFR3-targeted therapy in the post-immunotherapy setting include (B) primary immunotherapy resistance, (C) secondary immunotherapy resistance, and (D) enrichment of patients with immunotherapy-resistant tumors in trials of FGFR3-targeted therapy.