Figure 1.

Example of calculation of genomic instability indexes in a sample. The genomic profile is visualized in BlueFuse Multi v4.5. All chromosomes are diploid. Segmental aberrations are indicated with arrows for gains (above the horizontal line) and losses (under the line). Note that for the calculus of NGL we consider that in a diploid sample without chromosomal aberrations the quantity of genetic material is 2-fold the genome length (i.e., 2•2,881,030 kb in this case). CNA, copy number aberration; CNL, copy number load; iNGL, increased net genomic load; NGL, net genomic load; pCNL, positive copy number load.