Table 1.
Cox regression analyses for overall survival.
| HR | 95%CI | P | |
|---|---|---|---|
| Entire cohort (univariate) | |||
| CNA burden (%) | 0.99 | 0.95 to 1.03 | 0.667 |
| CNL (%) | 1.00 | 0.94 to 1.07 | 0.999 |
| NGL (%) | 0.97 | 0.87 to 1.08 | 0.566 |
| CNL genomic subtype | 0.99 | 0.62 to 1.59 | 0.971 |
| NGL genomic subtype | 0.77 | 0.48 to 1.24 | 0.285 |
| nCNL subgroup (univariatea) | |||
| MYCN status | 0.003 | ||
| non-MNA | ref | ref | ref |
| hetMNA | 0.49 | 0.14 to 1.64 | 0.244 |
| homMNA | 2.72 | 1.41 to 5.26 | 0.003 |
| MYCN status | |||
| non-MNA | ref | ref | ref |
| MNA | 1.61 | 0.88 to 2.94 | 0.120 |
| nCNL value (continuous) | |||
| All patients | 1.11 | 1.01 to 1.22 | 0.048 |
| non-MNA patients | 1.14 | 1.01 to 1.29 | 0.033 |
| MNA patients (hetMNA + homMNA) | 1.05 | 0.91 to 1.20 | 0.498 |
| homMNA patients | 1.05 | 0.90 to 1.22 | 0.544 |
| hetMNA patients | 1.23 | 0.84 to 1.82 | 0.293 |
| nCNL subgroup (multivariatea,b) | |||
| MYCN status | 0.002 | ||
| non-MNA | ref | ref | ref |
| hetMNA | 0.33 | 0.07 to 1.42 | 0.136 |
| homMNA | 2.77 | 1.40 to 5.49 | 0.004 |
| nCNL value (continuous) | 1.13 | 1.04 to 1.24 | 0.006 |
a
Age, stage, histology, ploidy, MYCN status, 11q loss, nCNL value (continuous). Only statistically significant variables are reported.
b
Stepwise forward. CI, confidence interval; CNA, copy number aberration; CNL, copy number load; hetMNA, heterogeneous MYCN amplification; homogeneous MYCN amplification; HR, hazard ratio; MNA, MYCN amplification; NGL, net genomic load; OS, overall survival; nCNL, negative copy number load; pCNL, positive copy number load.