Table 1.
Numbers of cases and controls in meta-analysis
|
European ancestry |
African ancestry |
European ancestry—case-control individuals |
|||||
|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | ||
| Case-control studies | |||||||
| CATS | 958 | 453 | .. | .. | 958 | 453 | |
| CADD | 397 | 699 | 59 | 55 | 397 | 699 | |
| CHDS | 201 | 420 | .. | .. | 201 | 420 | |
| FSCD | 226 | 314 | 199 | 401 | 226 | 314 | |
| COGEND Nico | 306 | 607 | 154 | 313 | 306 | 607 | |
| COGEND SAGE | 228 | 830 | 79 | 187 | 228 | 830 | |
| GEDI-GSMS | 81 | 491 | .. | .. | 81 | 491 | |
| ADAA | .. | .. | 1000 | 811 | .. | .. | |
| Total | 2397 | 3814 | 1491 | 1767 | 2397 | 3814 | |
| Family-based studies | |||||||
| BLTS | 170 | 1216 | .. | .. | 147 | 662 | |
| MCTFR | 449 | 1625 | .. | .. | 389 | 1185 | |
| Yale Penn 1 | 916 | 833 | 1189 | 1857 | 839 | 657 | |
| Yale Penn 2 | 557 | 497 | 355 | 548 | 557 | 495 | |
| bigCOGA | 2206 | 5053 | 813 | 1725 | 248 | 795 | |
| CEDAR | 64 | 148 | .. | .. | 64 | 148 | |
| OZ-ALC | 593 | 4893 | .. | .. | 470 | 1534 | |
| VTSABD | 99 | 734 | .. | .. | 94 | 361 | |
| IASPSAD | 104 | 613 | .. | .. | 84 | 353 | |
| Total | 5158 | 15 612 | 2357 | 4130 | 2892 | 6190 | |
| Summary statistics | |||||||
| Add health | 722 | 4071 | .. | .. | .. | .. | |
| PGC studies total | 8277 | 23497 | 3848 | 5897 | 5289 | 10 004 | |
| iPSYCH | 2758 | 53326 | 0 | 0 | 2758 | 53 326 | |
| deCODE | 6033 | 280 396 | 0 | 0 | 6033 | 280 396 | |
| Total (European ancestry) | 17 068 | 357 219 | .. | .. | 14 080 | 343 726 | |
| Total (Transancestral) | 20 916 cases;36 3116 controls | .. | .. | .. | .. | .. | |
ADAA=Alcohol Dependence in African Americans. BLTS= Brisbane Longitudinal Twin Study. CADD=Center on Antisocial Drug Dependence. CATS=Comorbidity and Trauma Study. CEDAR= Center for Education and Drug Abuse Research. CHDS=Christchurch Health and Development Study. COGA=Collaborative Study on the Genetics of Alcoholism. COGEND=Collaborative Genetic Study of Nicotine Dependence. FSCD=Family Study of Cocaine Dependence. GEDI=Gene-Environment-Development Initiative. GSMS=Great Smoky Mountains Study. IASPSAD=Irish Affected Sib-Pair Study of Alcohol Dependence. MCTFR= Minnesota Center for Twin and Family Research. OZ-ALC=Australian Alcohol and Nicotine Studies. SAGE=Study of Addiction: Genetics and Environment. VTSABD=Virginia Twin Studies of Adolescent Behavioral Development.