TABLE 1.
Nanoparticles | Target | Loaded cargo | Animal model | Application |
PLA NPs | Degraded elastin layer | DIR | CaCl2-induced rat model | Locating diseased vessels and avoiding normal areas (Sinha et al., 2014) |
PLA NPs | BB-94 | Suppress MMP activity and development of aorta (Nosoudi et al., 2015) | ||
BSA NPs | EDTA | Remove calcification in aneurysm (Lei et al., 2014) | ||
BSA NPs | EDTA and PGG | Reduced macrophage recruitment, MMP activity, calcification, and elastin degradation (Nosoudi et al., 2016) | ||
BSA NPs | PGG | PPE-induced mice model | Reversed the inflammatory marker (Dhital and Vyavahare, 2020) | |
Poly (ethylene glycol)-b-poly (γ-benzyl L-glutamate) (PEG-b-PBLG) | Defect (disruption and degeneration) in the aneurysm wall | RAP | elastase-induced rat model | AAA formation and wall inflammation were suppressed (Shirasu et al., 2016) |
ROS-responsive NPs | ROS | RAP | CaCl2-induced rat model | Reduced aneurysm diameter and removed calcification (Cheng et al., 2018) |