TABLE 1.

Nanoparticles for therapies.

Nanoparticles	Target	Loaded cargo	Animal model	Application
PLA NPs	Degraded elastin layer	DIR	CaCl2-induced rat model	Locating diseased vessels and avoiding normal areas (Sinha et al., 2014)
PLA NPs		BB-94		Suppress MMP activity and development of aorta (Nosoudi et al., 2015)
BSA NPs		EDTA		Remove calcification in aneurysm (Lei et al., 2014)
BSA NPs		EDTA and PGG		Reduced macrophage recruitment, MMP activity, calcification, and elastin degradation (Nosoudi et al., 2016)
BSA NPs		PGG	PPE-induced mice model	Reversed the inflammatory marker (Dhital and Vyavahare, 2020)
Poly (ethylene glycol)-b-poly (γ-benzyl L-glutamate) (PEG-b-PBLG)	Defect (disruption and degeneration) in the aneurysm wall	RAP	elastase-induced rat model	AAA formation and wall inflammation were suppressed (Shirasu et al., 2016)
ROS-responsive NPs	ROS	RAP	CaCl2-induced rat model	Reduced aneurysm diameter and removed calcification (Cheng et al., 2018)