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. 2020 Nov 5;8:584232. doi: 10.3389/fcell.2020.584232

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Copyright © 2020 Adamo, Delfino, Gatti, Bonato, Takam Kamga, Bazzoni, Ugel, Mercuri, Caligola and Krampera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunological signatures on primary MSCs, HS-5, and HS-27A cell lines. (A) Score plot of the first two PCs following the application of PCA on DEP included in C7 immunological signatures collection between primary MSCs, HS-5 and HS-27 cell lines. (B) Number of significantly down- and up-regulated pathways included in C7 immunological signatures collection between primary MSCs, HS-5 and HS-27 cell lines. (C–E) GSVA scores related to the expression of selected immunological signatures responsible for the immunoregulatory activity mediated by MSCs on primary MSCs, HS-5 and HS-27 cell lines. (n MSCs, HS-5, HS-27A = 11, 6, 4). PCs, principal components; PCA, principal component analysis; DEP, differentially expressed pathways; GSVA, gene set variation analysis.