Table 3.
Pooled odd ratio of clinicopathology variables in POLE-mutant EC vs. wild type
| Clinicopathology: POLE-mutant vs. wild type | Pooled odd ratio (95% CI) | No. of studies | I2 (95% CI, %) | p-value for I2 | Model |
|---|---|---|---|---|---|
| Stage I–II EC | 3.727 (2.063–6.732) | 8 | 0.00 (0.00–25.07) | .890 | Fixed effect |
| Stage III–IV EC | 0.269 (0.147–0.494) | 7 | 0.00 (0.00–53.51) | .716 | Fixed effect |
| Grade I–II EC | 0.400 (0.295–0.542) | 8 | 3.95 (0.00–69.18) | .399 | Fixed effect |
| Grade III EC | 2.246 (1.655–3.048) | 8 | 0.00 (0.00–29.91) | .865 | Fixed effect |
| LVI | 0.929 (0.643–1.341) | 8 | 6.95 (0.00–70.15) | .376 | Fixed effect |
| MI less than 50% | 1.481 (0.996–2.202) | 6 | 47.63 (0.00–79.24) | .089 | Random effect |
| Type I endometrioid histology | 1.721 (1.113–2.662) | 9 | 0.00 (0.00–68.45) | .486 | Fixed effect |
POLE, DNA polymerase epsilon; EC, endometrial carcinoma; CI, confidence interval; LVI, lymphovascular invasion; MI, myometrial invasion.