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The selectivity of BCL-2 family proteins. (A) BAK is inhibited predominantly by BCL-XL, MCL-1 and BFL-1, while BCL-2 contributes in some situations. However, BAX is probably inhibited by all of the pro-survival proteins. (B) Some BH3-only proteins, such as BAD and NOXA, are selective for subsets of their anti-apoptotic relatives, whereas other BH3-only proteins, particularly BIM, BID and PUMA, probably neutralize all of the anti-apoptotic proteins.
