Figure 4.

Intra-spinal NPC injection procedure and MRI evaluation of injection sites in a dog with chronic SCI. Fluoroscopic images of injection sites including original injury site (E), as well as an injection location cranial (F) and caudal (G) to the original injury site. T2-weighted MR images were obtained from dog 2, immediately prior to NPC injection (A,B) and 3 months after the intra-spinal injection procedure (C,D). Prior to NPC injection, there was a T2 hyper-intense lesion extending from T11 to T13 present within the spinal cord on both the transverse and sagittal images (red arrows A,B). Following the NPC injections, the lesion at 3 months did not change in size or extent compared to the pre-injection images, nor was there evidence of tumor growth at the injection site (red arrows C,D).