Table 4.

Phenotypic presentations (chameleons) of IgLON5 disease.

Sleep disorders	NREM and REM parasomnias (commonly vocalization, simple or finalistic limb movements, RBD), sleep apnea and stridor, excessive daytime somnolence
Bulbar dysfunction	Dysphagia, dysarthria, laryngeal stridor, recurrent acute respiratory failure (mimicking ALS or myasthenia)
PSP phenotype	VSGP and gait instability (restriction in upgaze is more than downgaze in contrast to PSP)
MSA phenotype	Parasomnia, dysautonomia (urinary dysfunction, episodic profuse sweating), stridor, parkinsonism, ataxia
Acute or subacute encephalopathy
Huntington's disease (HD) phenotype	Cognitive impairment with chorea
Orofacial dyskinesia	Facial myokymia and orolingual myorhythmia (mimicking Whipple's disease)
Motor neuron disease (MND) phenotype	Distal muscle atrophy, fasciculation
Stiff-person syndrome spectrum (SPS) phenotype	Peripheral nerve hyperexcitability with cramps, hyperekplexia, stiffness, myokymia, neuromyotonia
Cerebellar ataxia phenotype	Postural and intention tremor, titubation, gait, and limb ataxia
Cervical and truncal dystonia