Table 5.

Clinical and radiological clues for familial FTD with Parkinsonism.

Clinical clues	Radiological clues	Targeted gene	Suspected pathology
Early onset (3rd or 4th decade), PSP phenotype, vertical supranuclear gaze palsy	Symmetric fronto-temporal atrophy	MAPT	Tau
Late onset (5th or 6th decade), CBS phenotype, FTD-MND overlap, language involvement, apraxia, dyscalculia, visuospatial impairment, episodic memory involvement, hallucination	Asymmetric fronto-temporal atrophy, more posterior involvement (temporo-parietal, parieto-occipital), significant white matter hyperintensities	PGRN	TDP43
FTD-MND overlap, early cognitive, and/or behavioral symptoms, psychosis, hallucination, chorea (Huntington's disease phenocopy), positive family history of MND or FTD	Symmetric fronto-temporal and cerebellar atrophy	C9orf72	TDP43, Ubiquitin