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. 2020 Nov 5;10:588195. doi: 10.3389/fcimb.2020.588195

Figure 1.

Figure 1

In vitro, JWH-133 treatment attenuates LPS or S. pneumoniae-induced activation of glial cells. The expression of IL-1β (A), IL-6 (B), and TNF-α (C) was reduced by JWH-133 during challenge of astroglial cells by S. pneumoniae. JWH-11 also attenuated LPS-induced production of IL-β, but had not effect on IL-10 (D). Nitric oxide production (E) upon LPS- and S. pneumoniae activation was reduced by JWH-133. (For cytokines, n = 3 for each group; for NO: three independent experiments represented by black, gray, and white symbols; *p < 0.05; **p < 0.01, ***p < 0.001).