Figure 3.

Top10 transcription factor-binding site motifs that are enriched in the enhancer regions that are associated with differential methylation CpGs and differentially expressed genes in atopic asthma. Enhancer regions were identified in lung tissue in http://www.enhanceratlas.org.¹¹ The total number of enhancer regions that are associated with differential methylation and differentially expressed genes in atopic asthma was 26. TRANSFAC MATCH^19,20 software programs were used to identify the transcription factor motifs. For each transcription factor tested, among the 26 enhancer regions, sites refer to the number of hits found across all the input sequences. Furthermore, sequences represent the number of sequences in which the hits were made. See Figure 2 legend for expansion of abbreviation.