Table 1.

Top 30 eQTM Methylation CpGs That Are Located in Enhancer Regions of Their Target Genes in Lung Tissue

Chr	Probe ID	Position	Gene ID	TSSa	eQTM P	Distance From TSS
16	cg26259865	2880359	ZG16B	2880172	6.6 × 10-33	187
3	cg22012981	58522689	ACOX2	58522929	3.2 × 10-31	-240
3	cg16209444	58522771	ACOX2	58522929	4.5 × 10-25	-158
11	cg15453278	67134607	TBC1D10C	67171383	1.1 × 10-22	-36,776
11	cg21862992	68658383	MRPL21	68671303	8.6 × 10-21	-12,920
11	cg15453278	67134607	PTPRCAP	67205153	8.2 × 10-17	-70,546
6	cg25045942	33048291	HLA-DPA1	33041454	3.9 × 10-15	6,837
6	cg19053046	33048254	HLA-DPA1	33041454	6.8 × 10-15	6,800
15	cg10474377	42131658	JMJD7	42120282	2.1 × 10-14	11,376
17	cg04204452	1479213	SERPINF2	1646129	5.1 × 10-14	-166,916
11	cg21920570	63766787	FERMT3	63974151	1.7 × 10-13	-207,364
11	cg15995296	67210812	TBC1D10C	67171383	1.5 × 10-12	39,429
17	cg04204452	1479213	SERPINF1	1665218	1.5 × 10-12	-186,005
15	cg17163752	34729026	GOLGA8B	34875771	2.8 × 10-12	-146,745
12	cg21163444	54765670	NCKAP1L	54891494	1.3 × 10-11	-125,824
11	cg10161008	63766546	FERMT3	63974151	3.0 × 10-11	-207,605
6	cg17071868	33047056	HLA-DOA	32977389	1.3 × 10-10	69,667
11	cg21920570	63766787	CCDC88B	64107689	3.2 × 10-10	-340,902
3	cg16209444	58522771	KCTD6	58477822	1.0 × 10-9	44,949
8	cg20567768	22082066	SLC39A14	22224761	1.3 × 10-9	-142,695
12	cg22824738	54765988	NCKAP1L	54891494	2.9 × 10-9	-125,506
11	cg15995296	67210812	PTPRCAP	67205153	4.3 × 10-9	5,659
6	cg17071868	33047056	HLA-DPB1	33043702	8.9 × 10-9	3,354
17	cg01780984	79058859	BAIAP2	79008946	1.4 × 10-8	49,913
6	cg19053046	33048254	HLA-DPB1	33043702	1.7 × 10-8	4,552
11	cg10161008	63766546	CCDC88B	64107689	1.8 × 10-8	-341,143
5	cg23097826	149828748	RPS14	149829319	2.5 × 10-8	-571
19	cg25264268	427263	SHC2	460996	2.5 × 10-8	-33,733
12	cg11700959	7066664	LAG3	6881669	3.0 × 10-8	184,995
12	cg11700959	7066664	CD4	6898637	3.0 × 10-8	168,027

The eQTM analysis was conducted in nasal airway epithelium, and the enhancer regions and their target genes were identified in lung tissue (http://www.enhanceratlas.org).¹¹ A total of 81 eQTM CpGs that are located in enhancer regions of their target genes were found.

^aTSS is the transcription start site of the gene.