Table 3.
Top 30 eQTM Genes Identified in a Previous Transcriptome-Wide Association Study (TWAS) of Atopic Asthma28
| Gene | Chr | TWAS P |
No. of Associated Probes | Probe | Position | eQTM P |
|---|---|---|---|---|---|---|
| CST1 | 20 | 1.1 × 10-64 | 1 | cg14928764 | 23064608 | 5.5 × 10-10 |
| CLCA1 | 1 | 1.4 × 10-47 | 5 | cg22175412 | 86063985 | 9.7 × 10-15 |
| NTRK2 | 9 | 4.3 × 10-44 | 2 | cg09926027 | 87285693 | 1.5 × 10-18 |
| FETUB | 3 | 7.5 × 10-42 | 5 | cg25735294 | 186353721 | 2.6 × 10-18 |
| CPA3 | 3 | 3.4 × 10-39 | 5 | cg13235059 | 149192304 | 3.1 × 10-15 |
| ITLN1 | 1 | 8.7 × 10-38 | 10 | cg10094191 | 160855148 | 6.3 × 10-9 |
| CDH26 | 20 | 8.6 × 10-37 | 7 | cg06943251 | 57615398 | 2.1 × 10-18 |
| CCL26 | 7 | 2.2 × 10-35 | 5 | cg13053914 | 75511260 | 1.4 × 10-8 |
| CST2 | 20 | 4.0 × 10-35 | 1 | cg14928764 | 23064608 | 3.2 × 10-10 |
| C3orf70 | 3 | 8.3 × 10-35 | 9 | cg01390445 | 185271312 | 1.6 × 10-13 |
| TPSAB1 | 16 | 3.3 × 10-34 | 26 | cg00943124 | 1705667 | 3.9 × 10-14 |
| CISH | 3 | 3.0 × 10-32 | 9 | cg23005227 | 50645426 | 8.4 × 10-24 |
| TPSB2 | 16 | 8.0 × 10-30 | 20 | cg00943124 | 1705667 | 4.3 × 10-13 |
| ALOX15 | 17 | 3.4 × 10-29 | 11 | cg23387401 | 4582204 | 9.7 × 10-24 |
| CEP72 | 5 | 1.3 × 10-28 | 42 | cg04221910 | 616842 | 5.1 × 10-21 |
| SLC5A5 | 19 | 5.5 × 10-28 | 10 | cg15734198 | 17423023 | 1.7 × 10-12 |
| POSTN | 13 | 7.7 × 10-28 | 4 | cg03071245 | 37463034 | 1.7 × 10-9 |
| HS3ST4 | 16 | 5.2 × 10-27 | 4 | cg26725397 | 25937266 | 6.2 × 10-15 |
| PCSK6 | 15 | 1.4 × 10-26 | 11 | cg18749617 | 102028637 | 1.4 × 10-27 |
| WBSCR17 | 7 | 2.5 × 10-26 | 3 | cg01349903 | 71148142 | 5.4 × 10-12 |
| KYAT1 | 9 | 2.8 × 10-26 | 12 | cg13835688 | 130859454 | 1.6 × 10-16 |
| ANO1 | 11 | 5.1 × 10-26 | 7 | cg11058904 | 69987299 | 1.3 × 10-15 |
| ABO | 9 | 3.0 × 10-25 | 6 | cg11879188 | 136149908 | 7.4 × 10-18 |
| CMYA5 | 5 | 4.5 × 10-25 | 1 | cg14978242 | 79501131 | 1.2 × 10-7 |
| SLC24A3 | 20 | 1.3 × 10-23 | 3 | cg08371391 | 19739935 | 3.0 × 10-8 |
| GCNT4 | 5 | 1.1 × 10-22 | 2 | cg21158502 | 74348187 | 2.0 × 10-30 |
| SLC7A1 | 13 | 1.6 × 10-22 | 3 | cg17798847 | 30098432 | 8.3 × 10-7 |
| SLC45A4 | 8 | 1.8 × 10-22 | 7 | cg07140289 | 142299684 | 1.8 × 10-11 |
| DQX1 | 2 | 6.9 × 10-22 | 9 | cg02034222 | 74753281 | 4.4 × 10-17 |
| GSN | 9 | 9.4 × 10-22 | 6 | cg13928417 | 124498782 | 2.7 × 10-9 |
| KCNJ16 | 17 | 2.3 × 10-21 | 2 | cg13606025 | 68070495 | 7.8 × 10-10 |
| LINC01336 | 5 | 7.7 × 10-21 | 2 | cg21158502 | 74348187 | 1.6 × 10-16 |
| ZNF467 | 7 | 2.2 × 10-20 | 8 | cg07970948 | 149543165 | 3.3 × 10-19 |
| RUSC1 | 1 | 3.7 × 10-20 | 15 | cg23154272 | 154966068 | 2.3 × 10-16 |
| DHX35 | 20 | 4.7 × 10-20 | 1 | cg26604799 | 36789861 | 2.5 × 10-5 |
| DPP4 | 2 | 8.1 × 10-20 | 3 | cg22143064 | 162948592 | 5.9 × 10-27 |
| SOX13 | 1 | 8.4 × 10-20 | 3 | cg17000774 | 203154457 | 1.3 × 10-8 |
| SLC18A2 | 10 | 1.1 × 10-19 | 2 | cg03519180 | 119102524 | 1.2 × 10-6 |
| ST6GAL1 | 3 | 1.6 × 10-19 | 6 | cg25735294 | 186353721 | 1.1 × 10-20 |
| C20orf197 | 20 | 3.8 × 10-19 | 2 | cg16518142 | 58533713 | 3.9 × 10-8 |
| CA2 | 8 | 1.1 × 10-18 | 1 | cg05071334 | 86195487 | 1.1 × 10-5 |
| NPDC1 | 9 | 2.3 × 10-18 | 8 | cg13850871 | 139583773 | 2.6 × 10-11 |
| RTN4R | 22 | 3.2 × 10-18 | 3 | cg02333649 | 19471093 | 2.0 × 10-22 |
| FGF11 | 17 | 3.2 × 10-18 | 12 | cg22637538 | 7348327 | 3.1 × 10-11 |
| LOC100288152 | 5 | 5.0 × 10-18 | 15 | cg22572362 | 501938 | 1.6 × 10-8 |
| ELOVL5 | 6 | 5.8 × 10-18 | 1 | cg26516974 | 52475065 | 3.5 × 10-9 |
| CMIP | 16 | 1.0 × 10-17 | 1 | cg16583186 | 81526361 | 6.7 × 10-6 |
| ADAMTS9 | 3 | 1.4 × 10-17 | 11 | cg08765100 | 64211659 | 1.4 × 10-11 |
| CCK | 3 | 1.8 × 10-17 | 2 | cg07886398 | 42131702 | 1.0 × 10-8 |
Significance for both differential expression and differential methylation defined as FDR-P < .01. Genes shown sorted by TWAS P value. Only the most significantly associated probe per gene is presented.