Table 7.
Top 30 Most Significant eQTM Methylation-Gene Pairs in EVA-PR Cohort That Replicated in GSE65205
| Associated pairs |
EVA-PR |
GSE65205 |
EWAS (EVA-PR) |
|||||
|---|---|---|---|---|---|---|---|---|
| Probe | Gene | Beta | P | FDR | Beta | P | FDR | FDR |
| cg04511125 | THNSL2 | -0.9 | 1.1 × 10-36 | 9.2 × 10-32 | -0.81 | 1.2 × 10-6 | 1.4 × 10-5 | 7.3 × 10-3 |
| cg17252645 | LY6D | -1 | 6.1 × 10-36 | 5.0 × 10-31 | -1.6 | 1.5 × 10-8 | 4.4 × 10-7 | 4.1 × 10-2 |
| cg10807101 | GSTM3 | -0.43 | 3.4 × 10-33 | 2.3 × 10-28 | -0.68 | 4.9 × 10-7 | 6.8 × 10-6 | 7.6 × 10-4 |
| cg08450017 | CXCR6 | -0.46 | 2.0 × 10-32 | 1.3 × 10-27 | -0.59 | 2.4 × 10-10 | 1.7 × 10-8 | 2.6 × 10-4 |
| cg01850135 | NLRC3 | -0.34 | 8.3 × 10-32 | 5.2 × 10-27 | -0.9 | 1.5 × 10-11 | 2.0 × 10-9 | 5.6 × 10-4 |
| cg23161218 | ACAP1 | 0.31 | 1.2 × 10-31 | 7.5 × 10-27 | 0.29 | 2.1 × 10-4 | 1.0 × 10-3 | 2.3 × 10-3 |
| cg22012981 | ACOX2 | -0.86 | 3.2 × 10-31 | 1.9 × 10-26 | -0.35 | 1.1 × 10-2 | 2.6 × 10-2 | 3.3 × 10-8 |
| cg07786657 | CD247 | -0.35 | 4.6 × 10-31 | 2.7 × 10-26 | -0.37 | 3.9 × 10-9 | 1.5 × 10-7 | 8.0 × 10-4 |
| cg03546687 | IL32 | 0.59 | 2.4 × 10-29 | 1.3 × 10-24 | 0.75 | 5.0 × 10-6 | 4.5 × 10-5 | 3.1 × 10-3 |
| cg14527029 | HGD | -0.76 | 3.2 × 10-29 | 1.6 × 10-24 | -1.1 | 9.2 × 10-8 | 1.8 × 10-6 | 1.4 × 10-7 |
| cg11453837 | PSMB9 | -0.98 | 3.3 × 10-28 | 1.6 × 10-23 | -0.78 | 6.0 × 10-4 | 2.5 × 10-3 | 1.7 × 10-4 |
| cg27583010 | SEPT1 | -0.39 | 1.0 × 10-27 | 4.6 × 10-23 | -0.61 | 3.4 × 10-9 | 1.3 × 10-7 | 4.3 × 10-2 |
| cg18749617 | PCSK6 | -0.38 | 1.4 × 10-27 | 6.3 × 10-23 | -0.22 | 1.1 × 10-3 | 4.1 × 10-3 | 1.2 × 10-10 |
| cg08450017 | CCR5 | -0.36 | 2.8 × 10-27 | 1.2 × 10-22 | -0.54 | 3.3 × 10-9 | 1.3 × 10-7 | 2.6 × 10-4 |
| cg22143064 | DPP4 | -1.1 | 5.9 × 10-27 | 2.4 × 10-22 | -0.87 | 4.7 × 10-9 | 1.8 × 10-7 | 1.8 × 10-5 |
| cg07786657 | RCSD1 | -0.27 | 3.2 × 10-26 | 1.2 × 10-21 | -0.39 | 2.0 × 10-5 | 1.4 × 10-4 | 8.0 × 10-4 |
| cg08159663 | NLRC5 | -0.63 | 1.3 × 10-25 | 4.6 × 10-21 | -0.31 | 1.2 × 10-2 | 2.9 × 10-2 | 1.3 × 10-4 |
| cg19517476 | RASAL3 | -0.27 | 2.6 × 10-25 | 9.0 × 10-21 | -0.87 | 1.6 × 10-13 | 6.5 × 10-11 | 2.8 × 10-4 |
| cg12044599 | TBC1D10C | -0.32 | 3.5 × 10-25 | 1.2 × 10-20 | -0.71 | 3.6 × 10-7 | 5.4 × 10-6 | 3.5 × 10-3 |
| cg26833120 | LCK | 0.46 | 4.8 × 10-25 | 1.6 × 10-20 | 0.73 | 4.8 × 10-5 | 3.1 × 10-4 | 1.6 × 10-3 |
| cg02297541 | HLA-DMA | 0.49 | 5.3 × 10-25 | 1.8 × 10-20 | 0.91 | 6.6 × 10-10 | 3.7 × 10-8 | 9.2 × 10-4 |
| cg06148175 | ACY3 | -0.65 | 5.7 × 10-25 | 1.9 × 10-20 | -0.35 | 2.8 × 10-3 | 8.9 × 10-3 | 2.7 × 10-2 |
| cg00676801 | STAT1 | -0.55 | 7.0 × 10-25 | 2.2 × 10-20 | -1.3 | 8.2 × 10-8 | 1.7 × 10-6 | 8.5 × 10-4 |
| cg12911952 | SLC22A18AS | -0.39 | 1.2 × 10-24 | 3.8 × 10-20 | -1.1 | 2.7 × 10-7 | 4.3 × 10-6 | 9.4 × 10-5 |
| cg05141234 | HLA-DMB | 0.57 | 1.8 × 10-24 | 5.3 × 10-20 | 0.75 | 3.5 × 10-7 | 5.3 × 10-6 | 2.9 × 10-4 |
| cg00945209 | TMC8 | -0.54 | 2.2 × 10-24 | 6.5 × 10-20 | -1.1 | 1.8 × 10-9 | 8.2 × 10-8 | 1.7 × 10-2 |
| cg09878888 | LPXN | 0.24 | 3.2 × 10-24 | 9.1 × 10-20 | 0.35 | 6.7 × 10-3 | 1.8 × 10-2 | 1.5 × 10-4 |
| cg00676801 | STAT4 | -0.33 | 3.4 × 10-24 | 9.7 × 10-20 | -0.57 | 2.0 × 10-8 | 5.5 × 10-7 | 8.5 × 10-4 |
| cg23387401 | ALOX15 | -0.37 | 9.7 × 10-24 | 2.6 × 10-19 | -0.64 | 6.2 × 10-8 | 1.4 × 10-6 | 1.0 × 10-9 |
| cg13443575 | CCL5 | 0.54 | 1.3 × 10-23 | 3.5 × 10-19 | 0.77 | 7.8 × 10-6 | 6.6 × 10-5 | 5.5 × 10-3 |
Only eQTM probes that are associated with atopic asthma in EVA-PR cohort (FDR-P < .05) are presented. Replication defined as FDR P < .05 with effect in the same direction as in EVA-PR. Only one gene per methylation probe presented.