Table 1.
Demographics and Clinical Characteristics of the Analytic Datasets
| Characteristic | MGI | UKB |
|---|---|---|
| Total participants | 38,360 | 408,595 |
| Females, n (%) | 20,141 (52.5%) | 220,896 (54.1%) |
| Mean age, years (SD) | 56.8 (16.2) | 56.9 (8.0) |
| Median number of visits per participant | 45 | not available |
| Median time (years) between first and last visit | 5.5 | not available |
| Median number of unique ICD9 codes | 36a | 2 |
| Median number of unique ICD10 codes | 31a | 6 |
| Number of PheCodes with more than 50 cases | 1,689 | 1,419 |
| Any cancer diagnosis | 20,751 (54.1%) | 69,190 (16.9%) |
| 20 Most Common Cancer Traits in MGI (PheCode) | ||
| Basal cell carcinoma (172.21)b | 2,988 (7.79%) | not available |
| Melanomas of skin, dx or hx (172.1) | 2,701 (7.04%) | 2,682 (0.66%) |
| Breast cancer [female] (174.1) | 2,605 (12.93%) | 12,483 (5.65%) |
| Cancer of prostate (185) | 2,432 (13.35%) | 5,977 (3.18%) |
| Squamous cell carcinoma (172.22)b | 1,917 (5.00%) | not available |
| Cancer of bladder (189.2) | 1,575 (4.11%) | 2,413 (0.59%) |
| Colorectal cancer (153) | 1,196 (3.12%) | 4,585 (1.12%) |
| Non-Hodgkins lymphoma (202.2) | 1,141 (2.97%) | 1,810 (0.44%) |
| Cancer of connective tissue (170.2) | 1,097 (2.86%) | 331 (0.08%) |
| Malignant neoplasm of kidney, except pelvis (189.11) | 1,083 (2.82%) | 1,033 (0.25%) |
| Colon cancer (153.2) | 941 (2.45%) | 3,108 (0.76%) |
| Myeloproliferative disease (200) | 886 (2.31%) | 992 (0.24%) |
| Cancer of bronchus; lung (165.1) | 874 (2.28%) | 2,232 (0.55%) |
| Thyroid cancer (193) | 798 (2.08%) | 347 (0.08%) |
| Malignant neoplasm of rectum, rectosigmoid junction, and anus (153.3) | 669 (1.74%) | 2,167 (0.53%) |
| Malignant neoplasm of uterus (182) | 643 (3.19%) | 1,285 (0.58%) |
| Nodular lymphoma (202.21) | 632 (1.65%) | 365 (0.09%) |
| Cancer of tongue (145.2) | 550 (1.43%) | 310 (0.08%) |
| Leukemia (204) | 545 (1.42%) | 1,665 (0.41%) |
| Cancer of brain (191.11) | 483 (1.26%) | 525 (0.13%) |
The provided characteristics are based on the European subjects in MGI and white British subjects in UKB for which phenotype and imputed genotype data were available. SD, standard deviation.
a
ICD9/10-CM codes
b
Skin cancer sub-types