Table 2.
Overview of GWAS Sources and PRS Construction Methods
| Source of Summary Statistics |
PRS Construction Method |
|||
|---|---|---|---|---|
| Fixed p Value Thresholdsa | P&Tb | Lassosum | ||
| GWAS Catalog | yes | yes | no | |
| Large GWAS | yes | yes | yes, if full GWAS | |
| UKB GWAS | PHECODE | yes | yes | yes |
| FINNGEN | yes | yes | yes | |
| ICD10 | yes | yes | yes | |
| PHESANT | yes | yes | yes | |
Multiple PRSs were constructed per trait of interest depending on availability of GWAS summary statistics.
a
Uncorrelated variants with p value ≤ 5 × 10−5, 5 × 10−6, 5 × 10−7, 5 × 10−8 (“GWAS Hits”), or 5 × 10−9
b
LD pruning and p value thresholding