Table 2.
Logistic Regression Analysis of Clinician Perception of Change in Management and Clinical Utility of rWGS, rWES, and urWGS in NICU, PICU, and CVICU Infants
| Independent Variable | Description | Odds Ratio (95% CI) | p Value |
|---|---|---|---|
| Outcome: Change in Management | |||
| Test type | rWES | reference | – |
| rWGS | 1.41 (0.65–3.1) | 0.39 | |
| urWGS | 2.37 (0.72–7.75) | 0.15 | |
| Result type | negative | reference | – |
| positive | 10.07 (4.74–22.35) | <0.0001 | |
| Turnaround time | days, accession to 1st report | 0.92 (0.85–0.99) | 0.03 |
| Outcome: Clinical Utility | |||
| Test type | rWES | reference | – |
| rWGS | 0.77 (0.38–1.57) | 0.48 | |
| urWGS | 1.79 (0.41–12.61) | 0.48 | |
| Result type | negative | reference | – |
| positive | 3.22 (0.98–14.71) | 0.08 | |
| Change in management | no | reference | – |
| yes | 6.69 (1.83–43.3) | 0.01 | |
| Turnaround time | days, accession to 1st report | 0.98 (0.93–1.05) | 0.59 |
CI, confidence intervals. Multiple logistic regression was used to evaluate which variables were associated with changes in management and clinician perception of clinical utility. Test type, result type, and turnaround time were included as predictor variables for both outcomes. Change in management was also included as a predictor variable in the model for clinical utility. Odds ratios and 95% confidence intervals are reported. A significance cutoff of α = 0.05 was used for all analyses. All analyses were conducted in R v.3.3.3.