Table 4.
5- and 10-Year Cumulative Risks of Contralateral Breast Cancer by the 313-Variant PRS (PRS313) for Different Age Groups with Death as Competing Risk
|
5-Year Cumulative CBC Risks (%) Range by Age |
10-Year Cumulative CBC risks (%) Range by Age |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age at First Breast Cancer Diagnosis (years) | 5thPercentile PRS313 | 10thPercentile PRS313 | 50thPercentile PRS313 | 90thPercentile PRS313 | 95thPercentile PRS313 | 5thPercentile PRS313 | 10thPercentile PRS313 | 50thPercentile PRS313 | 90thPercentile PRS313 | 95thPercentile PRS313 |
| 30–34 | 1.9–3.1 | 2.1–3.4 | 2.7–4.5 | 3.6–5.9 | 4.0–6.5 | 3.1–4.1 | 3.4–4.5 | 4.5–5.9 | 5.9–7.7 | 6.5–8.5 |
| 35–39 | 0.8–2.1 | 0.9–2.3 | 1.2–3.0 | 1.5–3.9 | 1.7–4.3 | 2.1–3.5 | 2.3–3.8 | 3.0–5.0 | 3.9–6.6 | 4.3–7.2 |
| 40–44 | 1.5–2.8 | 1.7–3.1 | 2.2–4.1 | 2.9–5.3 | 3.2–5.9 | 2.8–4.6 | 3.1–5.0 | 4.1–6.6 | 5.3–8.6 | 5.9–9.4 |
| 45–49 | 1.4–2.5 | 1.5–2.7 | 2.0–3.6 | 2.6–4.7 | 2.9–5.2 | 2.5–3.9 | 2.7–4.3 | 3.6–5.6 | 4.7–7.4 | 5.2–8.1 |
| 50–54 | 1.4–2.8 | 1.5–3.0 | 1.9–4.0 | 2.6–5.2 | 2.8–5.8 | 2.8–4.5 | 3.0–4.9 | 4.0–6.4 | 5.2–8.4 | 5.8–9.3 |
| 55–59 | 1.6–3.1 | 1.8–3.4 | 2.3–4.5 | 3.1–5.9 | 3.4–6.5 | 3.1–4.8 | 3.4–5.2 | 4.5–6.9 | 5.9–9.0 | 6.5–9.9 |
| 60–64 | 1.7–3.3 | 1.9–3.6 | 2.5–4.7 | 3.3–6.2 | 3.6–6.8 | 3.3–5.0 | 3.6–5.4 | 4.7–7.1 | 6.2–9.3 | 6.8–10.2 |
| 65–70 | 1.5–3.2 | 1.6–3.5 | 2.1–4.6 | 2.8–6.1 | 3.1–6.7 | 3.2–4.1 | 3.5–4.5 | 4.6–5.9 | 6.1–7.7 | 6.7–8.5 |
Abbreviations: PRS, polygenic risk score; CBC, contralateral breast cancer. Coefficients to construct the PRS313 are shown in Table S3. The PRS313 was standardized by SD = 0.61, in line with Mavaddat et al.7 The CBC incidences for each age group were calculated based on incidence data from the Netherlands Cancer Registry1 and relative risks estimated as described in the Material and Methods. Death was taken into account as competing risk.