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Immune microenvironment triggers MES signature in GBM. A bilateral interaction between GBM and tumor associated macrophages/microglia (TAMs) through soluble factors and other regulatory mechanisms can induce mesenchymal transformation. MES tumors are characterized by the presence of different types of T‐cells, neutrophils, macrophages, and microglia. On the other hand, natural killer (NK) cells and tumor‐infiltrating lymphocytes (TILs) are predominant in PN tumors.
