Table 5.
Comparison of the clinical characteristics and biochemical parameters of the alleles of ghrelin rs696217 gene genotype in the post-adolescent male patients with acne vulgaris
| Parameter | CC (n = 24) | AA (n = 4) | CA (n = 7) | P-value |
|---|---|---|---|---|
| Age [years] | 28.0 ±4.9 | 23.2 ±2.6 | 30.8 ±6.9 | NS |
| Disease duration [years] | 6.5 ±2.8 | 5.5 ±2.5 | 6.8 ±3.1 | NS |
| GAGS | 17.5 ± 17.5 | 15.4 ±18.4 | 20.0 ±17.8 | NS |
| Weight [kg] | 73.6 ±8.1 | 72 ±4.5 | 75 ±7.3 | NS |
| BMI [kg/m2] | 24 ±2.3 | 23.1 ±0.8 | 23 ±2.5 | NS |
| WHR | 0.9 ±0.0 | 0.9 ±0.1 | 0.9 ±0.0 | NS |
| Systolic BP [mm Hg] | 112 ±11.7 | 115 ±5.7 | 111.2 ±7.8 | NS |
| Diastolic BP [mm Hg] | 75 ±6.9 | 76.2 ±7.5 | 77.1 ±5.6 | NS |
| FPG [mg/dl] | 88.4 ±6.8 | 87.5 ±7.8 | 87.5 ±8.8 | NS |
| Basal insulin [mU/l] | 11.3 ±5.7 | 6.8 ±2.9 | 16.2 ±9.7 | NS |
| HOMA-IR | 2.5 ±1.3 | 1.5 ±0.6 | 3.5 ±2.1 | NS |
| LDL-C [mg/dl] | 81 ±29.6 | 114.2 ±9.9 | 94.9 ±21.5 | NS |
| Triglyceride [mg/dl] | 122.6 ±53.6 | 85.5 ±45.7 | 90.1 ±29.4 | NS |
| TC [mg/dl] | 152 ±32.6 | 181.7 ±31 | 174.8. ±32.8 | NS |
| HDL-C [mg/dl] | 53.7 ±14.9 | 59.2 ±20.8 | 61.2 ±23.7 | NS |
| FSH [mIU/ml] | 3.4 ±1.5 | 4.3 ±2.8 | 4 ±1.7 | NS |
| LH [mIU/ml] | 4.9 ±1.9 | 6.6 ±0.3 | 4.5 ±1.7 | NS |
| Total testosterone [ng/ml] | 5.1 ±1.6 | 6.4 ±2.9 | 5.3 ±2.3 | NS |
| SHBG [nmol/l] | 28.3 ±11.2 | 44 ±38.3 | 31.2 ±13.3 | NS |
| FAI | 21.4 ±17.3 | 18.1 ±6.7 | 20.1 ±14 | NS |
| DHEAS [µg/dl] | 338.1 ±86.3ª | 522.2 ±165.2 | 226.3 ±101.1b | < 0.05 |
| Ghrelin [pg/ml] | 4.8 ±6.7 | 2.5 ±1.9 | 4.4 ±3.4 | NS |
Data were presented as mean ± SD, The p-values < 0.05 were assessed as statistically significant. N – number of volunteers, NS – non-significant, GAGS – global acne grading score, BMI – body mass index, WHR – waist to hip ratio, BP – blood pressure, FPG – fasting plasma glucose, HOMA-IR – homeostatic model assessment of insulin resistance, LDL-C – low-density lipoprotein cholesterol, TC – total cholesterol, HDL-C – high-density lipoprotein cholesterol, LH – luteinizing hormone, FSH – follicle stimulating hormone, SHBG – sex hormone binding globulin, FAI – free androgen index, DHEAS – dehydroepiandrosterone sulphate. ªp < 0.05; CC allele group vs. AA allele group. bp < 0.05; CC allele group vs. CA allele group.