Table 2.
Histological features of cutaneous and laryngeal granulomas in A-T
| Histological features | |
|---|---|
| Skin biopsy of a lesion on the arm: | |
| Atypical granuloma annulare with central necrosis and fibrosis | |
| Biopsy of a granuloma of the larynx (epiglottis): | |
| Reactive T lymphocyte infiltration: collection of lymphoid cells with T CD3+CD8+ predominance with CD68+ histiocytes | |
| 30% of cells showing an expression of the nuclear proliferation marker Ki-67 | |
| TdT (Terminal deoxynucleotidyl transferase) | |
| CD34 (hematopoietic progenitor cell antigen) | |
| CALLA (common acute lymphoblastic leukemia antigen) | |
| CD1a (antigen-presenting molecule on Langerhans cells and dendritic cells) | |
| LMP EBV (latent membrane protein, EBV oncoprotein) | |
| MPO (neutrophil myeloperoxidase) | |
| CD30 (TNF receptor superfamily member 8, TNFRSF, contributing to lymphomagenesis) | |
| not detected | |
| CD4+ : CD8+ ratio << 1 | |