Sex differences in cardiovascular risk factors and disease in non-alcoholic steatohepatitis patients. Unique sex differences in the prevalence of important cardiovascular risk factors and cardiovascular diseases were observed in patients with non-alcoholic steatohepatitis. Males had higher rates of atherosclerotic cardiovascular disease including a higher rate of coronary artery disease (27.4% vs 16.3%; P < 0.001), coronary artery stenting (0.9% vs 0.4%; P < 0.001), coronary artery bypass surgery (6.9% vs 2.6%; P < 0.001), heart failure (20.4% vs 19.0%; P < 0.001), and peripheral vascular disease (6.8% vs 5.0%; P < 0.001). Females had a lower prevalence of dyslipidemia (35.4% vs 40.6%; P < 0.001), hypertension (66.0% vs 68.7%; P < 0.001), and smoking (26.7% vs 34.5%; P < 0.001), but had higher rates of obesity (40.5% vs 38.1%; P < 0.001).