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. Author manuscript; available in PMC: 2020 Nov 19.
Published in final edited form as: J Med Chem. 2019 Apr 19;62(9):4444–4455. doi: 10.1021/acs.jmedchem.8b01943

Figure 8.

Figure 8.

(A) Schematic depicting the rapid metabolism of Cfz by microsomal epoxide hydrolase (mEH) to the inactive diol. (B) Quantification of the remaining levels of Cfz or 9 following the incubation with rat liver homogenate containing active mEH and peptidase activities for 5, 10, and 20 min, respectively. Data presented as mean ± SD.