TABLE 1.
Characteristics, laboratory data, and clinical management of patients with or without elevation of alanine aminotransferase
| Characteristic | Normal‐ALT (n = 29) | High‐ALT (n = 31) |
|---|---|---|
| Age (years) | 45.2 (16.6) | 46.0 (13.6) |
| Sex | ||
| Male | 59% (17) | 84% (26) |
| Female | 41% (12) | 16% (5) |
| Bodyweight (kg) | 61.4 (10.9) | 90.1 (33.9) |
| Height (cm) | 166.9 (8.6) | 172.7 (11.3) |
| BMI (kg/m2) | 22.0 (3.2) | 29.9 (9.6) |
| BT (°C)† | 37.3 (0.9) | 37.7 (0.9) |
| SpO2 (%)‡ | 96.8 (1.6) | 95.5 (2.0) |
| AST (U/L)† | 26.0 (10.2) | 67.1 (37.7) |
| ALT (U/L)† | 21.8 (8.5) | 97.4 (59.1) |
| ALP (U/L)† | 203.1 (61.5) | 286.8 (179.8) |
| γGTP (U/L)† | 39.0 (29.3) | 138.8 (121.0) |
| LDH (U/L)† | 247.8 (119.0) | 345.5 (134.6) |
| Albumin (g/dL)‡ | 3.8 (0.5) | 3.6 (0.6) |
| Total bilirubin (mg/dL)† | 0.6 (0.2) | 0.7 (0.3) |
| CRP (mg/dL)† | 2.8 (3.8) | 7.7 (8.4) |
| Ferritin† (log10 ng/mL) | 2.5 (0.4) | 2.9 (0.4) |
| PT‐INR | 1.06 (0.07) | 1.07 (0.08) |
| Fibrinogen (mg/dL) | 427.8 (111.7) | 517.0 (150.7) |
| FDP elevated | 37% (10) | 74% (23) |
| Not elevated (<2.5 μg/mL) | 63% (17) | 26% (8) |
| D‐dimer elevated | 19% (5) | 61% (19) |
| Not elevated (<1.0 μg/mL) | 81% (22) | 39% (12) |
| BUN (mg/dL)† | 13.9 (4.3) | 12.9 (3.3) |
| Creatinine (mg/dL)† | 0.8 (0.3) | 0.8 (0.2) |
| White blood cell (×100/μL)† | 52.0 (15.3) | 74.0 (26.1) |
| Lymphocyte count (/μL)‡ | 1295.8 (470.9) | 1352.9 (706.8) |
| Platelet (×10 000/μL)‡ | 21.2 (8.7) | 25.7 (8.5) |
| Hemoglobin (g/dL)‡ | 13.4 (1.6) | 14.0 (1.6) |
| Antivirals (F/LR/HC/S)§ | 8:1:2:0 | 7:2:8:2 |
| Days of hospitalization | 9.6 (3.9) | 9.5 (5.2) |
| Days from onset to admission | 8.2 (4.8) | 10.9 (5.7) |
| Days from onset to discharge | 17.8 (3.4) | 20.3 (6.0) |
Data are shown as the mean (standard deviation) or % (number).
†Maximum or ‡minimum value during hospitalization.
§
F, favipiravir; LR, lopinavir/ritonavir; HC, hydroxychloroquine; S, ciclesonide. One patient took HC and S and two patients took F and HC.
γGTP, γ‐glutamyl transpeptidase; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; BT, body temperature; BUN, blood urea nitrogen; CRP, C‐reactive protein; FDP, fibrin/fibrinogen degradation products; LDH, lactase dehydrogenase; SpO2, percutaneous saturation of oxygen.