Table 1.
Comparison of laboratory parameters at admission in patients with COVID‐19 who did and did not develop macrophage activation syndrome (MAS)
| MAS patients admission (mean ± SD; n = 21) | Non‐MAS patients admission (mean ± SD; n = 79) | p | |
|---|---|---|---|
| Age (year) | 69.6 ± 12.6 | 43.4 ± 18.2 | .001 |
| WBC (/µl) | 8770 ± 7007.7 | 6641.5 ± 2244.3 | .02 |
| Lymphocytes (/µl) | 831.4 ± 388.6 | 1779.4 ± 870.4 | .001 |
| Neutrophils (/µl) | 7159.1 ± 6189.3 | 4201.5 ± 1883.2 | .001 |
| NLR | 12.8 ± 14.8 | 3.1 ± 2.7 | .001 |
| AST (U/L) | 41.5 ± 18.8 | 29.9 ± 19.1 | .01 |
| ALT (U/L) | 35.1 ± 27.2 | 28.6 ± 23.5 | .33 |
| LDH (U/L) | 439.2 ± 205.4 | 268.1 ± 111.9 | .001 |
| GGT (U/L) | 61.2 ± 51.7 | 33.2 ± 22.6 | .001 |
| ALP (U/L) | 84.8 ± 36.9 | 78.5 ± 41.9 | .54 |
| Sodium (mmol/L) | 137.9 ± 6 | 139.1 ± 3.1 | .22 |
| Potassium (mmol/L) | 4.1 ± 0.7 | 4.2 ± 0.4 | .72 |
| Creatine (mg/dL) | 1.6 ± 1.7 | 0.9 ± 0.5 | .001 |
| Prothrombin time (s) | 20.1 ± 12.1 | 14.7 ± 3.3 | .001 |
| CRP (mg/dL) | 176.4 ± 87.6 | 24.7 ± 36.6 | .001 |
| Troponin‐I (ng/dL) | 253 ± 580.7 | 10.6 ± 26.2 | .001 |
| PaO2/FiO2 | 209.4 ± 64.8 | 325.4 ± 47.2 | .001 |
| d‐Dimer (ng/ml) | 2947.1 ± 3642.8 | 876.2 ± 1706.9 | .001 |
| Ferritin (ng/ml) | 1093.8 ± 1485.5 | 322.4 ± 151.9 | .001 |
Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; COVID‐19, coronavirus disease 2019; GGT, gamma‐glutamyltransferase; LDH, lactate dehydrogenase; MAS, macrophage activation syndrome; NLR, neutrophil/lymphocyte ratio; SD, standard deviation; WBC, white blood cells.