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. 2020 Nov 11;22(6):939–948. doi: 10.1002/cbic.202000595

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© 2020 Wiley‐VCH GmbH

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Synthetic routes of RDV. Abbreviations: Ac₂O, acetic anhydride; DMSO, dimethyl sulfoxide; n‐BuLi, n‐butyllithium; TMSCl, trimethylsilyl chloride; TMSCN, trimethylsilyl cyanide; BF₃, boron fluoride; Et₂O, diethyl ether; BCl₃, boron trichloride; MgCl₂, magnesium chloride; NMI, N‐methylimidazole; OP(OMe)₃, trimethyl phosphate; TfOH. triflic acid; TMSOTf, trimethylsilyl trifluoromethanesulfonate; HPLC, high pressure liquid chromatography; H₂SO₄, sulfuric acid; PhMgCl, phenylmagnesium chloride; i‐PrMgCl ⋅ LiCl, isopropylmagnesium chloride lithium chloride; i‐Pr₂O, diisopropyl ether; i‐Pr₂Net, N,N‐diisopropylethylamine; MgCl₂, magnesium chloride; HCl, hydrochloric acid.