TABLE 2.

Peak Laboratory Values

Laboratory Findings	Liver Injury Cohort (AST or ALT ≥3 times ULN) (n = 109)	Control Cohort (Normal AST/ALT) (n = 67)	P
Creatinine (mg/dL)	1.3 (0.8, 4.9)	1.2 (0.8, 2.2)	0.13
AST (U/L)	187 (134, 263)	30 (25, 33)	<0.001
ALT (U/L)	180 (140, 258)	20 (15, 29)	<0.001
Alkaline phosphatase (U/L)	134 (97, 209)	84 (66, 117)	<0.001
Total bilirubin (mg/dL)	1.1 (0.8, 1.7)	0.6 (0.4, 0.8)	<0.001
Prothrombin time (seconds)	16.7 (14.8, 18.6)*	14.9 (13.9, 17.2)*	0.02
INR	1.4 (1.2, 1.6)*	1.2 (1.1, 1.5)*	0.03
LDH (U/L)	706 (569, 996)	421 (329, 518)	<0.001
CRP (mg/L)	247 (141, 329)	168 (83, 260)	<0.001
Ferritin (ng/mL)	2,973 (1,643, 5,368)	751 (407, 1,984)	<0.001
D‐dimer (µg/mL)	3.8 (1.6, 14.7)	2.3 (1.1, 9.7)	0.08
Creatinine kinase (U/L)	288 (145, 1,258)*	88 (37, 242)*	<0.001
Uric acid (mg/dL)	4.8 (3.9, 8.8)*	5.9 (4.0, 9.3)*	0.59
Procalcitonin (ng/mL)	0.9 (0.3, 5.0)	0.24 (0.08, 0.94)	<0.001
Cytokine markers
IL‐6 (nl 0‐5 pg/mL)	121.0 (66.0, 245.8)	71.8 (33.8, 123.0)	<0.001
IL‐8 (nl 0‐5 pg/mL)	50.1 (34.6, 93.5)	42.7 (29.8, 78.1)	0.3
TNF‐α (nl 0‐22 pg/mL)	24.6 (20.1, 34.9)	26.0 (17.1, 38.3)	0.69
IL‐1β (nl 0‐5 pg/mL)	0.6 (0.3, 1.0)	0.6 (0.3, 0.9)	0.83

Values expressed as median (IQR) unless otherwise stated; ULN defined as 40 U/L.

^*>10% missing values.

Abbreviation: nl, normal level.