Table 4.
Prognostic values of clinical variables for predicting progression-free survival and overall survival in 63 patients with metastatic renal cell carcinoma analyzed by using univariate and multivariate Cox proportional hazards regression models.
| Risk factor | Risk category | Univariate | Multivariate | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PFS | OS | PFS | OS | ||||||||
| HR | p | HR | p | HR | 95% CI | p | HR | 95% CI | p | ||
| IMDC risk classification | Poor | 4.53 | 0.033 | 14.28 | < 0.001 | 1.72 | – | 0.189 | 2.88 | 1.10–8.47 | 0.030 |
| Nephrectomy | Not performed | 1.51 | 0.219 | 6.22 | 0.013 | 0.24 | – | 0.622 | |||
| Spindle histology | Positive | 5.16 | 0.023 | 10.71 | 0.001 | 1.96 | – | 0.162 | 2.87 | 1.40–11.00 | 0.020 |
| NLR | 2.9 or more | 3.51 | 0.061 | 8.72 | 0.003 | 1.83 | – | 0.176 | |||
| CRP | 0.5 or more | 4.87 | 0.027 | 12.50 | 0.002 | 1.63 | 1.70–4.02 | 0.031 | 3.07 | 0.97–7.75 | 0.058 |
| Metastatic organ | 4 or more | 5.22 | 0.022 | 7.30 | 0.007 | 2.21 | – | 0.137 | 1.20 | – | 0.274 |
Statistically significant factors are shown in bold.
PFS progression-free survival, OS overall survival, HR Hazard ratio, CI confidence interval, IMDC International metastatic renal cell carcinoma database consortium, NLR neutrophil lymphocyte ratio, CRP C reactive protein.