Figure 7.

The silencing of lncRNA XIST and the upregulation of let‐7c‐5p both enhance ALP activity. A, ALP staining results of subchondral bone osteoblasts in RA (× 200); B, the ratio of ALP positive cells in response to the treatment of sh‐lncRNA XIST, let‐7c‐5p mimic, let‐7c‐5p inhibitor, and sh‐lncRNA XIST + let‐7c‐5p inhibitor. All data were measurement data, expressed as mean ± standard deviation. Comparisons among multiple groups were conducted by one‐way ANOVA with Tukey's post hoc test; *, P < .05 vs the blank group or NC group; ^#, P < .05 vs the sh‐lncRNA XIST group