Table 4.
Diagnostic performance of cytology, ARMS‐PCR and ddPCR in patients with pathological diagnosis following surgery (n = 90)
| Surgical pathology | ||||||
|---|---|---|---|---|---|---|
| Negative (n = 7) | Positive (n = 83) | Sensitivity | Specificity | PPV | NPV | |
| Bethesda classification | ||||||
| I | 3 | 3 | ||||
| II | 1 | 4 | ||||
| III‐IV | 1 | 4 | ||||
| V‐VI | 2 | 72 | 86.7% | 71.4% | 97.3% | 25.0% |
| ARMS‐PCR | ||||||
| Negative | 7 | 14 | ||||
| Positive | 0 | 69 | 83.1% | 100% | 100% | 33.3% |
| ddPCR | ||||||
| Negative | 7 | 10 | ||||
| Positive | 0 | 73 | 91.3% | 100% | 100% | 41.2% |
| Bethesda V/VI + ARMS‐PCR | ||||||
| Negative | 5 | 2 | ||||
| Positive | 2 | 81 | 97.6% | 71.4% | 97.6% | 71.4% |
| Bethesda V/VI + ddPCR | ||||||
| Negative | 5 | 1 | ||||
| Positive | 2 | 82 | 98.8% | 71.4% | 97.6% | 83.3% |
Bethesda classification: I, specimens nondiagnostic/unsatisfactory (ND/UNS); II, benign; III, atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS); IV, follicular neoplasm/suspicious for a follicular neoplasia (FN/SFN); V, suspicious for malignancy (SM); VI, malignancy.
Abbreviations: NPV, negative predictive value; PPV, positive predictive value.