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. 2020 Nov 18;10:20105. doi: 10.1038/s41598-020-76708-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

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Drug efficacy testing. For the first study, untreated control (n = 5); 5-FU + BEV (n = 6), 5-FU + OXA + BEV (n = 6); 5-FU + IRI + BEV (n = 5). For the second study, untreated control (n = 6); YON + OXA (n = 4), REG (n = 7); SEL + REG (n = 5). (A) Study 1, comparison of tumor volume before treatment; at 2 weeks; and after treatment. (B) Study 1, comparison of relative tumor volume before treatment; at 2 weeks; and after 4 weeks. (C) Study 2, comparison of tumor volume before treatment and after treatment. (D) Study 2, comparison of relative tumor volume before treatment and after treatment. The data are shown as mean + standard deviation (SD). (E) Study 1, representative images of a harvested tumor in each group. The white arrow shows the intrahepatic metastasis along with the primary implanted tumor. Scale bar: 10 mm. (F) Study 2, representative images of harvested tumor in each group. (G): Study 1, representative images of the control and treated tumors. (H) Study 2, representative images of the control and treated tumors.