Table 1.
Treatment protocol for the colon-cancer liver-metastasis PDOX model. The mice were randomized into 4 different groups. For study one, the treatment period was 4 weeks. For study two, the treatment period was 2 weeks.
| Group | Treatment | Route | Dose | Frequency |
|---|---|---|---|---|
| Study 1 | ||||
| 1 | Control | ip | 200 μL (PBS) | Once a week |
| 2 | 5-Fluorouracil | ip | 50 mg/kg | Once a week |
| Irinotecan | ip | 40 mg/kg | Twice a week | |
| Bevacizumab | ip | 5 mg/kg | Twice a week | |
| 3 | 5-Fluorouracil | ip | 50 mg/kg | Once a week |
| Oxaliplatum | ip | 6 mg/kg | Once a week | |
| Bevacizumab | ip | 5 mg/kg | Twice a week | |
| 4 | Fluorouracil | ip | 50 mg/kg | once a week |
| Bevacizumab | ip | 5 mg/kg | Twice a week | |
| Study 2 | ||||
| 1 | Control | ip | 200 μL (PBS) | Once a week |
| 2 | Yondelis | iv | 0.15 mg/kg | Once a week |
| Oxaliplatum | ip | 6 mg/kg | Twice a week | |
| 3 | Regorafenib | po | 30 mg/kg | Once a day |
| 4 | Selumetinib | po | 20 mg/kg | Once a day |
| Regorafenib | po | 30 mg/kg | Once a day | |