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. 2020 Nov 18;10:20085. doi: 10.1038/s41598-020-77077-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Th2-dependent cytokine production induced by SARS-CoV-2 S-2P adjuvanted with CpG 1018, aluminum hydroxide, or CpG 1018/aluminum hydroxide in mice. The antisera of BALB/c mice (N = 6 per group) were collected at 2 weeks after the second injection, the splenocytes were harvested and stimulated as in Fig. 6. After 20 h incubation, the levels of IL-4 (left), IL-5 (middle), and IL-6 (right) released from the splenocytes were analyzed. For detection of cytokines, the culture supernatant was harvested to analyze the levels of cytokines by ELISA.

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