FIGURE 2.

Obligate anaerobic taxa are predominantly differentially abundant between mucosal region and disease. Volcano plots of differential abundance meta-analysis data exhibiting that the presence of CD leads to the alterations in Bacteroidetes and Firmicutes taxa that are classified as obligate anaerobes in the colonic mucosa (A), with the relative of abundance of obligate anaerobic taxa increased in the presence of CD reflecting the aerotolerance analysis seen in the ileum (B). Within-disease non-IBD mucosa shows that the colonic mucosa is a signficantly more anaerobic environment compared to the ileal mucosa (C); this difference is greatly reduced in the presence of disease. Differential taxa abundance meta-analysis conducted using DESeq2 and LEfSe on all phylogenetic levels. Global P values from combined DESeq2 and LEfSe analyses constructed using Fisher method (FDR ≤ 0.05). Taxa with sp labels indicate that an exact species could not be ascertained.