Table 3.

Subgroup analysis for the association between the miR-200 family and the survivals.

	OS					RFS
				Heterogeneity					Heterogeneity
Subgroup analysis	No. of studies	Pooled HR (95% CI)	P value	I2 (%)	P	No, of studies	Pooled HR (95% CI)	P value	I2 (%)	P
Overall	6	0.50 (0.40–0.62)	<.01	0	.89	5	0.48 (0.36–0.65)	<.01	0	1.00
Study setting
Asia	3	0.54 (0.40–0.74)	<.01	0	.85	3	0.46 (0.31–0.69)	.01	0	.98
Europe	3	0.46 (0.34–0.62)	<.01	0	.61	2	0.51 (0.33–0.78)	<.01	0	.90
Year of publication
Before 2015	2	0.47 (0.27–0.79)	<.01	0	.32	2	0.49 (0.32–0.74)	<.01	0	.74
After 2015	4	0.51 (0.40–0.64)	<.01	0	.87	3	0.48 (0.32–0.72)	<.01	0	.99
NOS score
6	1	0.59 (0.41–0.85)	<.01	0	.79	–	–	–	–	–
7	2	0.45 (0.32–0.63)	<.01	0	.75	3	0.46 (0.31–0.69)	<.01	0	.98
8	3	0.48 (0.31–0.72)	<.01	0	.61	2	0.51 (0.33–0.78)	<.01	0	.90

CI = confidence interval, HR = hazard ratio, NOS = Newcastle-Ottawa Scale, OS = overall survival, RFS = recurrence-free survival.