Table 3.

Univariate and multivariate analyses of prognostic factors.

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Age
< 65 years	Reference		Reference
≥ 65 years	1.705 (1.161–2.503)	.006	1.427 (0.960–2.122)	.078
Histologic type
Differentiated	Reference
Undifferentiated	1.163 (0.777–1.741)	.463
Others	0.554 (0.281–1.091)	.087
Depth of invasion
T1	Reference		Reference
T2	2.882 (1.494–5.556)	.001	1.833 (0.912–3.681)	.088
T3	3.111 (1.794–5.395)	<.001	1.540 (0.803–2.954)	.193
T4	8.897 (5.235–15.121)	<.001	3.924 (2.044–7.533)	<.001
Lymph node metastasis
N0	Reference		Reference
N1	2.248 (1.237–4.085)	.007	1.527 (0.787–2.962)	.210
N2	5.064 (2.967–8.643)	<.001	3.113 (1.712–5.660)	<.001
N3	7.736 (4.741–12.623)	<.001	5.388 (2.873–10.102)	<.001
TNM Stage
I	Reference
II	3.013 (1.750–5.188)	<.001
III	8.234 (5.017–13.513)	<.001
BMI group
Normal	Reference		Reference
Underweight	2.421 (1.316–4.452)	.004	2.355 (1.238–4.482)	.009
Overweight and obese	0.945 (0.625–1.430)	.001	1.736 (1.077–2.799)	.023
SMI group
High SMI group	Reference		Reference
Low SMI group	1.451 (0.987–2.132)	.058	1.607 (1.037–2.490)	.033