Table 2. Discriminative performance of serum MMP-2 and MMP-3.

Serum Biomarker	Comparison	AUC	95% CI
	T1 vs Control	0.61	0.50–0.71
MMP-2	T2 vs Control	0.69	0.58–0.79
	T3 vs Control	0.67	0.56–0.78
	T1 vs Control	0.53	0.42–0.64
MMP-3	T2 vs Control	0.54	0.42–0.66
	T3 vs Control	0.58	0.46–0.70
MMP-2 and MMP-3	T1 vs Control	0.62	0.53–0.71

The overall performance of serum MMP-2 and MMP-3 at different measurement time points (T1, T2, and T3) and combined on discriminating between dogs with and without osteoarthritis. The discriminative performance is measured using area under the ROC curve (AUC). T1: initial visit, T2: 4-week recheck, T3: 12-week recheck time points.