Table 5. Correlation between synovial fluid biomarkers (i.e., IL-8, KC, MCP-1) and histopathological grade of biopsied synovial membrane.

Synovial membrane histological grading	Synovial fluid biomarkers
	IL-8	KC	MCP-1
	CC (P value)	CC (P value)	CC (P value)
Synoviocyte
•Proliferation	0.32 (0.007)		0.38 (<0.001)
•Hypertrophy			0.35 (<0.001
Sum of Synoviocyte scores			0.38 (<0.001)
Inflammatory infiltrate
•PMNs		0.31 (0.02)	0.49 (<0.001)
•Fibrin	0.32 (0.007)		0.55(<0.001)
•Lymphoplasmacytic infiltrate	0.35 (0.002)	0.31(0.017)	0.55 (<0.001)
•Lymphoid aggregates/follicles)			0.36 (0.001)
Sum of Inflammatory infiltrate scores	0.34(0.004)	0.32(0.011)	0.56 (<0.001)
Synovial Stroma
•Villous hyperplasia			0.45(<0.001)
•Proliferative fibroblasts/fibrocytes			0.45(<0.001)
•Proliferative blood vessels	0.33 (0.000)	0.32 (0.011)	0.6(<0.001)
•Cartilage/bone detritus
•Hemosidrosis	0.34 (0.003)		0.50 (<0.001)
Sum of Synovial Stroma scores	0.34 (0.003)		0.54 (<0.001)
Sum of all scores	0.35 (0.001)		0.54 (<0.001)

The P value and Spearman’s correlation coefficient (CC) are provided with significance set at P < 0.05.