Fig 5. In-utero exposure to ART does not disrupt the development of every primitive reflex.

Postnatal day of successful acquisition of surface righting reflex (A), auditory reflex (B), air righting reflex (C), and open field traversal (D) for male and female pups exposed in-utero to control (CTRL, white bars), ATV/r/ABC/3TC (light grey bars), or ATV/r/TDF/FTC (dark grey bars). Data are mean ± SEM (n = 11–34 pups/group). A mixed effects model was used to examine differences between control and treatment arms (fixed effect) accounting for litter effects (random effect) stratified by sex. No statistically significant differences were observed. ATV/r, ritonavir-boosted atazanavir; ABC, abacavir; 3TC, lamivudine; TDF, tenofovir; FTC, emtricitabine; CTRL, control.